Chronic granulomatous disease is associated with lack of NADPH activity in phagocytes and characterized by recurrent bacterial and fungal infections as well as exagerated inflammation. This paper shows that the excessive inflammation can be attributed to the lack of NAPPH-derived reactive oxygen which is required for the conversion of tryptophan to kynurenine.
- Luigina Romani
- Francesca Fallarino
- Paolo Puccetti
