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Showing 1–13 of 13 results
Advanced filters: Author: Angie Hinrichs Clear advanced filters

  • While the number of SARS-CoV-2 genome sequences grew to over 15 million, the Ultrafast Sample placement on Existing tRees (UShER) tool suite maintained a comprehensive phylogenetic tree in near real time. This experience, and critical performance improvements throughout the pandemic, provide valuable lessons for rapidly scaling analyses.

    • Angie Hinrichs
    • Cheng Ye
    • Russell Corbett-Detig
    Comments & Opinion
    Nature Genetics
    Volume: 56, P: 4-7

  • The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

    • Richard M. Durbin
    • David Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 467, P: 1061-1073

  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218

  • The next step after sequencing a genome is to figure out how the cell actually uses it as an instruction manual. A large international consortium has examined 1% of the genome for what part is transcribed, where proteins are bound, what the chromatin structure looks like, and how the sequence compares to that of other organisms.

    • Ewan Birney
    • John A. Stamatoyannopoulos
    • Pieter J. de Jong
    Research
    Nature
    Volume: 447, P: 799-816

  • The UCSC SARS-CoV-2 Genome Browser (https://genome.ucsc.edu/covid19.html) is an adaptation of our popular genome-browser visualization tool for this virus, containing many annotation tracks and new features, including conservation with similar viruses, immune epitopes, RT–PCR and sequencing primers and CRISPR guides. We invite all investigators to contribute to this resource to accelerate research and development activities globally.

    • Jason D. Fernandes
    • Angie S. Hinrichs
    • Maximilian Haeussler
    Comments & Opinion
    Nature Genetics
    Volume: 52, P: 991-998