Nature Search

A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles

A mix-and-go system enables the rapid prototyping of antibody formulations, allowing control of their orientation on the surface of LNPs for specific cell targeting, significantly improving the ex vivo and in vivo deliveries of mRNA.

Moore Z. Chen
Daniel Yuen
Angus P. R. Johnston
ResearchOpen Access04 Aug 2025
Nature Nanotechnology

Volume: 20, P: 1273-1284
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation.

Anna S. E. Cuomo
Daniel D. Seaton
Oliver Stegle
ResearchOpen Access10 Feb 2020
Nature Communications

Volume: 11, P: 1-14
A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

A method called vessel isolation and nuclei extraction for sequencing (VINE-seq) produces a molecular map of vascular and perivascular cell types in the human brain and reveals their contributions to Alzheimer’s disease risk.

Andrew C. Yang
Ryan T. Vest
Tony Wyss-Coray
Research14 Feb 2022
Nature

Volume: 603, P: 885-892
Situating emotion regulation in autism and ADHD through neurodivergent adolescents’ perspectives

Georgia Pavlopoulou
Susie Chandler
Darren Webb
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.

Kin Man Suen
Fabian Braukmann
Eric Alexander Miska
ResearchOpen Access25 Aug 2020
Nature Communications

Volume: 11, P: 1-13
Stable-isotope labeling with amino acids in nematodes

A method for performing quantitative proteomics experiments in Caenorhabditis elegans using stable-isotope labeling with amino acids in cell culture (SILAC) is described. The authors used the method to identify heat shock–responsive proteins in worms. Also in this issue, Fredens et al. describe a very similar method.

Mark Larance
Aymeric P Bailly
Angus I Lamond
Research28 Aug 2011
Nature Methods

Volume: 8, P: 849-851
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

Milagros Balbín
Antonio Fueyo
Carlos López-Otín
Research28 Sept 2003
Nature Genetics

Volume: 35, P: 252-257
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

Mutations in LSM11 and RNU7-1, which encode components of the replication-dependent histone pre-mRNA–processing complex, cause an autoinflammatory syndrome due to enhanced interferon signaling mediated by the cGAS–STING pathway, showing an essential role for nuclear histones in suppressing the immunogenicity of self-DNA.

Carolina Uggenti
Alice Lepelley
Yanick J. Crow
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1364-1372
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monomeric state to a tetramer is essential for necroptosis signalling.

Emma J. Petrie
Jarrod J. Sandow
James M. Murphy
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-15
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

Variation in antibody levels elicited by the COVID-19 vaccine ChAdOx1 nCov-19 is linked to specific major histocompatibility complex class II alleles, providing insight into the breadth of immune response among vaccinated individuals.

Alexander J. Mentzer
Daniel O’Connor
Julian C. Knight
ResearchOpen Access13 Oct 2022
Nature Medicine

Volume: 29, P: 147-157
Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B

Katherine Bronson
Jewel Banik
Angus M. MacNicol
ResearchOpen Access10 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
An acidic microenvironment produced by the V-type ATPase of Euprymna scolopes promotes specificity during Vibrio fischeri recruitment

Production of an acidic microenvironment by the juvenile host’s epithelial V-type ATPase promotes the recruitment of its specific bacterial symbiont from the ambient environment.

Alexis C. Hargadon
Joani W. Viliunas
Margaret J. McFall-Ngai
ResearchOpen Access18 Dec 2024
Communications Biology

Volume: 7, P: 1-15
Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and cytoplasmic actins, and suggest that it may be a protective mechanism to prevent excessive contraction-induced myofibre damage.

John T. Olthoff
Angus Lindsay
James M. Ervasti
ResearchOpen Access30 Nov 2018
Nature Communications

Volume: 9, P: 1-14
Purinergic receptors in the carotid body as a new drug target for controlling hypertension

A small-molecule antagonist of the P2X3 receptor reduces blood pressure in hypertensive rats via its action on the carotid body, pointing to a new drug target for treating hypertension.

Wioletta Pijacka
Davi J A Moraes
Julian F R Paton
Research05 Sept 2016
Nature Medicine

Volume: 22, P: 1151-1159
A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

A small molecule identified from high-throughput screening and optimization specifically stabilizes a disease-linked CLRN1 protein, delivering it to its site of action at the plasma membrane and preserving hearing in a new mouse model for Usher syndrome type III.

Kumar N Alagramam
Suhasini R Gopal
Yoshikazu Imanishi
Research25 Apr 2016
Nature Chemical Biology

Volume: 12, P: 444-451
No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system

Amy McLeman
Pawel Sierocinski
Michiel Vos
ResearchOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-6
Radiative recombination of confined electrons at the MgZnO/ZnO heterojunction interface

Sumin Choi
David J. Rogers
Cuong Ton-That
ResearchOpen Access07 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like particle (SC2-VLP) infectivity

Christina Pantoja
Francisco M. Acosta
Peter W. Ramirez
ResearchOpen Access15 May 2025
Scientific Reports

Volume: 15, P: 1-10
Radiative cooling: Energy savings from the sky

Environmental heat sinks beyond local air are available for use with normal air conditioners to increase their efficiency. A study has exploited outer space and the atmosphere as remote sinks to demonstrate daytime sub-ambient fluid cooling and its application in reducing the energy needed to cool an interior.

Geoff Smith
Angus Gentle
News & Views04 Sept 2017
Nature Energy

Volume: 2, P: 1-2
Particle generation, functionalization and sortase A–mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

This protocol describes sortase A-mediated site-specific bioconjugation of single-chain antibodies to iron oxide particles for magnetic resonance imaging and to layer-by-layer capsules for drug delivery.

Christoph E Hagemeyer
Karen Alt
Karlheinz Peter
Protocols11 Dec 2014
Nature Protocols

Volume: 10, P: 90-105
The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs

Jewel Banik
Ana Rita Silva Moreira
Angus M. MacNicol
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-15
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer

Gustavo A. Arias-Pinilla
Angus G. Dalgleish
Helmout Modjtahedi
ResearchOpen Access17 Jan 2020
Scientific Reports

Volume: 10, P: 1-13
Author Correction: Radiative recombination of confined electrons at the MgZnO/ZnO heterojunction interface

Sumin Choi
David J. Rogers
Cuong Ton-That
Amendments and CorrectionsOpen Access16 Nov 2017
Scientific Reports

Volume: 7, P: 1
GWAS: heritability missing in action?

Angus J Clarke
David N Cooper
Correspondence17 Mar 2010
European Journal of Human Genetics

Volume: 18, P: 859-861

Search

A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

Situating emotion regulation in autism and ADHD through neurodivergent adolescents’ perspectives

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

Stable-isotope labeling with amino acids in nematodes

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B

An acidic microenvironment produced by the V-type ATPase of Euprymna scolopes promotes specificity during Vibrio fischeri recruitment

Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

Purinergic receptors in the carotid body as a new drug target for controlling hypertension

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system

Radiative recombination of confined electrons at the MgZnO/ZnO heterojunction interface

Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like particle (SC2-VLP) infectivity

Radiative cooling: Energy savings from the sky

Particle generation, functionalization and sortase A–mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer

Author Correction: Radiative recombination of confined electrons at the MgZnO/ZnO heterojunction interface

GWAS: heritability missing in action?

Search

Quick links

Search

Filter By:

Search

Quick links