Integrin-linked kinase (Ilk) is a multifunctional protein that binds β-integrin cytoplasmic domains and regulates actin dynamics through the recruitment of actin binding regulatory proteins such as α- and β-parvin. In mice, genetic evidence is now provided that the kinase activity of Ilk is not essential for mammalian development but that an interaction between Ilk and α-parvin is critical for kidney development.
- Anika Lange
- Sara A. Wickström
- Reinhard Fässler
