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Showing 1–5 of 5 results
Advanced filters: Author: Anja Erika Hauser Clear advanced filters
  • Owing to recent advances in imaging technology, the behaviour of B cells in germinal centres can now be visualized in three dimensionsin vivo. What have we learnt from such studies and how might this change our understanding of antibody affinity maturation?

    • Anja E. Hauser
    • Mark J. Shlomchik
    • Ann M. Haberman
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 499-504
  • Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.

    • Marta Ferreira-Gomes
    • Andrey Kruglov
    • Mir-Farzin Mashreghi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P signaling inhibits this directional migration.

    • Kerry Tedford
    • Michael Steiner
    • Klaus-Dieter Fischer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15