Obstetric complications are less frequent in subsequent than in first pregnancies, and one potential difference is immunological adaptation of the mothers. Here authors compare the immunological landscape of the uterine microenvironment in mice during first and subsequent pregnancies to find that tolerogenic regulatory T cells recognising foetal antigens accumulate in subsequent pregnancies to enable better foetal development and overall pregnancy outcome.
- Kristin Thiele
- Christopher Urbschat
- Petra Clara Arck
