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Showing 1–5 of 5 results
Advanced filters: Author: Anke Diemert Clear advanced filters

  • Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and reduces neuroinflammation, identifying a possible target for multiple sclerosis treatment.

    • Jana K. Sonner
    • Audrey Kahn
    • Manuel A. Friese
    ResearchOpen Access
    Nature Immunology
    P: 1-13

  • Obstetric complications are less frequent in subsequent than in first pregnancies, and one potential difference is immunological adaptation of the mothers. Here authors compare the immunological landscape of the uterine microenvironment in mice during first and subsequent pregnancies to find that tolerogenic regulatory T cells recognising foetal antigens accumulate in subsequent pregnancies to enable better foetal development and overall pregnancy outcome.

    • Kristin Thiele
    • Christopher Urbschat
    • Petra Clara Arck
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the risk or severity of infections in newborns.

    • Ina Annelies Stelzer
    • Christopher Urbschat
    • Petra Clara Arck
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19