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The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

A novel study led by scientists in Lübeck, Germany, shows that SARS-CoV-2-infected brain endothelial cells undergo cell death due to the cleavage of NEMO by the viral protease M^pro, potentially causing cerebral COVID-19 and ‘long COVID’ symptoms.

Jan Wenzel
Josephine Lampe
Markus Schwaninger
ResearchOpen Access21 Oct 2021
Nature Neuroscience

Volume: 24, P: 1522-1533
An integrated personal and population-based Egyptian genome reference

North Africans are underrepresented in current genome-wide data sets. Here, the authors provide an Egyptian genome reference, consisting of de novo assembly of the genome of an Egyptian individual and genome-wide genetic variation from a representative cohort of 110 Egyptian individuals.

Inken Wohlers
Axel Künstner
Saleh Ibrahim
ResearchOpen Access18 Sept 2020
Nature Communications

Volume: 11, P: 1-10
Ruxolitinib mediated paradoxical JAK2 hyperphosphorylation is due to the protection of activation loop tyrosines from phosphatases

Sivahari P. Gorantla
Lorenz Oelschläger
Nikolas von Bubnoff
ResearchOpen Access23 Apr 2025
Leukemia

Volume: 39, P: 1678-1691
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy

Christopher C. Udoye
Christina N. Rau
Rudolf A. Manz
ResearchOpen Access16 Sept 2022
Mucosal Immunology

Volume: 15, P: 1375-1388
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Misa Hirose
Paul Schilf
Saleh M. Ibrahim
ResearchOpen Access12 Apr 2018
Scientific Reports

Volume: 8, P: 1-15