Nature Search

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance

Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous cell carcinoma subtypes that display prognostic differences.

Ankur Chakravarthy
Ian Reddin
Tim R. Fenton
ResearchOpen Access07 Oct 2022
Nature Communications

Volume: 13, P: 1-17
Publisher Correction: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

Parinaz Mehdipour
Sajid A. Marhon
Daniel D. De Carvalho
Amendments and Corrections02 Mar 2021
Nature

Volume: 591, P: E20
TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

Changes in ECM are of predictive value in pancreatic and colorectal cancer prognosis. Here, the authors perform a pan-cancer analysis and find a subset of ECM genes that is linked to TGF-β signalling signature and is correlated with immunotherapy failure.

Ankur Chakravarthy
Lubaba Khan
Daniel D. De Carvalho
ResearchOpen Access08 Nov 2018
Nature Communications

Volume: 9, P: 1-10
Author Correction: Pan-cancer deconvolution of tumour composition using DNA methylation

Ankur Chakravarthy
Andrew Furness
Tim R. Fenton
Amendments and CorrectionsOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1
Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

A cell-free DNA-methylation sequencing assay accurately identifies different brain tumor types using plasma samples.

Farshad Nassiri
Ankur Chakravarthy
Daniel D. De Carvalho
Research22 Jun 2020
Nature Medicine

Volume: 26, P: 1044-1047
Sensitive tumour detection and classification using plasma cell-free DNA methylomes

An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.

Shu Yi Shen
Rajat Singhania
Daniel D. De Carvalho
Research14 Nov 2018
Nature

Volume: 563, P: 579-583
A clinically applicable integrative molecular classification of meningiomas

Multi-omics datasets are integrated to generate a unified and clinically informed molecular classification of meningiomas.

Farshad Nassiri
Jeff Liu
Gelareh Zadeh
Research25 Aug 2021
Nature

Volume: 597, P: 119-125
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

Inverted-repeat Alu elements are the main source of drug-induced immunogenic double-stranded RNAs, which are destabilized by the RNA deaminase ADAR1, thereby limiting activation of the immune response.

Parinaz Mehdipour
Sajid A. Marhon
Daniel D. De Carvalho
Research21 Oct 2020
Nature

Volume: 588, P: 169-173
Author Correction: Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes

Pier Vitale Nuzzo
Jacob E. Berchuck
Matthew L. Freedman
Amendments and Corrections07 Sept 2020
Nature Medicine

Volume: 26, P: 1663
Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

McGaha and colleagues show that phagocytosis of apoptotic cells leads to activation of the transcription factor AhR and production of the cytokine IL-10 in phagocytes, in a manner dependent on the recognition of DNA.

Rahul Shinde
Kebria Hezaveh
Tracy L. McGaha
Research14 May 2018
Nature Immunology

Volume: 19, P: 571-582
Pan-cancer deconvolution of tumour composition using DNA methylation

Determining the extent of immune cell infiltration into solid tumours is essential for adequate therapeutic response. Here the authors develop a DNA methylation-based approach for tumour cell fraction deconvolution and analyse tumour composition and genomics across a wide spectrum of solid cancers.

Ankur Chakravarthy
Andrew Furness
Tim R. Fenton
ResearchOpen Access13 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes

A cell-free DNA-methylation sequencing assay accurately identifies renal cell carcinoma using plasma and urine samples.

Pier Vitale Nuzzo
Jacob E. Berchuck
Matthew L. Freedman
Research22 Jun 2020
Nature Medicine

Volume: 26, P: 1041-1043
Epigenetic therapy in immune-oncology

In this Review, Jones et al. present the evidence that epigenetic therapies can induce the expression of endogenous retroviruses and cancer–testis antigens normally silenced by DNA methylation in most somatic cells. As a consequence, a state of viral mimicry is evoked in cancer cells, leading to an innate immune response. Understanding this process has implications for combination therapy with epigenetic drugs and immunotherapies to improve clinical outcomes for patients with cancer.

Peter A. Jones
Hitoshi Ohtani
Daniel D. De Carvalho
Reviews05 Feb 2019
Nature Reviews Cancer

Volume: 19, P: 151-161

Search

Filter By:

Search

Quick links