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An integrative systems genetic analysis of mammalian lipid metabolism

The integration of liver and plasma quantitative lipidomic and proteomic data from 107 distinct mouse strains provides important insights into regulators of mammalian lipid metabolism.

Benjamin L. Parker
Anna C. Calkin
Brian G. Drew
Research27 Feb 2019
Nature

Volume: 567, P: 187-193
Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle

Bond et al. show that inducible PolG mutation in muscle causes mtDNA damage and muscle wasting. This is driven by the integrated stress response (ISR) and reduction in folate intermediates, linking impaired folate metabolism with ISR/disease induction.

Simon T. Bond
Emily J. King
Brian G. Drew
ResearchOpen Access08 Mar 2025
Nature Communications

Volume: 16, P: 1-21
The clot thickens—oxidized lipids and thrombosis

Oxidized products of low-density lipoproteins (LDLs) activate platelets through CD36, demonstrating a link between deregulated lipoprotein levels, oxidative stress and thrombosis (pages 1086–1095).

Shaun P Jackson
Anna C Calkin
News & Views01 Sept 2007
Nature Medicine

Volume: 13, P: 1015-1016
Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

The genetic determinants of sex-specific differences in obesity are still incompletely understood. Here, the authors demonstrate that adipocyte specific loss of Trim28 in committed adipocytes leads to sex specific differences in the development of obesity, and that this phenotype is associated with altered metabolic flexibility and lipid metabolism.

Simon T. Bond
Emily J. King
Brian G. Drew
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
IDOL regulates systemic energy balance through control of neuronal VLDLR expression

Emerging findings identify important roles for brain lipoprotein receptors in the control of whole-body energy homoeostasis. Here Lee et al. reveal that IDOL-mediated regulation of VLDLR abundance in neurons, but not in peripheral metabolic tissues, regulates food intake and energy expenditure.

Stephen D. Lee
Christina Priest
Cynthia Hong
Research28 Oct 2019
Nature Metabolism

Volume: 1, P: 1089-1100
Compression force sensing regulates integrin α_IIbβ₃ adhesive function on diabetic platelets

Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin α_IIbβ₃ on discoid diabetic platelets and that platelet aggregates can be eliminated by PI 3-kinase inhibition, but not by anti-thrombotics aspirin or clopidogrel.

Lining Ju
James D. McFadyen
Shaun P. Jackson
ResearchOpen Access14 Mar 2018
Nature Communications

Volume: 9, P: 1-16
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

Ritchie et al. use polygenic scores to identify plasma proteins with causal roles in cardiometabolic disease.

Scott C. Ritchie
Samuel A. Lambert
Michael Inouye
Research08 Nov 2021
Nature Metabolism

Volume: 3, P: 1476-1483
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Nuclear receptors integrate hormonal and nutritional signals, resulting in changes to key metabolic pathways within the body. The liver X receptor (LXR) and the farnesoid X receptor (FXR), which are activated by oxysterols and bile acids, respectively, have essential roles in the regulation of cholesterol and bile acid metabolism but are also key integrators of sterol, fatty acid and glucose metabolism.

Anna C. Calkin
Peter Tontonoz
Reviews14 Mar 2012
Nature Reviews Molecular Cell Biology

Volume: 13, P: 213-224
The association between lithium use and neurocognitive performance in patients with bipolar disorder

Katherine E. Burdick
Caitlin E. Millett
John R. Kelsoe
Research29 Apr 2020
Neuropsychopharmacology

Volume: 45, P: 1743-1749
A roadmap of strategies to support cardiovascular researchers: from policy to practice

Cardiovascular researchers face a range of challenges, including reduced grant funding, job insecurity and a lack of diversity in leadership roles. In this Roadmap article, Marques and colleagues propose strategies to overcome these challenges, focusing on three key areas: capacity building, research funding and fostering diversity and equity.

Niamh Chapman
Emma E. Thomas
Francine Z. Marques
Reviews16 May 2022
Nature Reviews Cardiology

Volume: 19, P: 765-777
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis

Vipavee Niemsiri
Sara Brin Rosenthal
John R. Kelsoe
ResearchOpen Access29 Mar 2023
Molecular Psychiatry

Volume: 29, P: 6-19
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder

Michael J. McCarthy
Heather Wei
John R. Kelsoe
Research16 Nov 2018
Neuropsychopharmacology

Volume: 44, P: 620-628

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