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Showing 1–2 of 2 results
Advanced filters: Author: Anna E Grzegorzewicz Clear advanced filters

  • As drug-resistant strains of Mycobacterium tuberculosis continue to emerge, antitubercular drugs with novel mechanisms of action are in high demand. Here, the authors show that ebselen is an inhibitor of M. tuberculosisantigen 85 and reveal the mechanism of inhibition.

    • Lorenza Favrot
    • Anna E. Grzegorzewicz
    • Donald R. Ronning
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • An adamantyl urea derivative identified as a potent bactericidal compound against Mycobacterium species and multidrug-resistant M. tuberculosis targets a late step in biogenesis of very-long-chain cell wall–bound mycolic acids—by inhibiting the transport of the fatty acids across the bacterial plasma membrane.

    • Anna E Grzegorzewicz
    • Ha Pham
    • Mary Jackson
    Research
    Nature Chemical Biology
    Volume: 8, P: 334-341