Zhuang et al. investigate how low oxygen levels affect HIV-1 replication in cell culture models. They find that the hypoxia-induced transcription factor HIF-2α represses HIV transcription and that low oxygen reduces the reactivation of latent HIV, suggesting that the hypoxic environment in the lymph node may influence HIV replication and latency.
- Xiaodong Zhuang
- Isabela Pedroza-Pacheco
- Jane A. McKeating
