Nature Search

Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Research20 Dec 2022
Nature Genetics

Volume: 55, P: 89-99
Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function

Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human oligodendrocytes and improves mitochondrial action in all brain cells.

Nina-Lydia Kazakou
Nadine Bestard-Cuche
Anna Williams
ResearchOpen Access30 Aug 2025
Nature Communications

Volume: 16, P: 1-14
CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents

Increasing age and disease progression negatively impact remyelination in Multiple Sclerosis. Here authors show that genetically edited human oligodendrocyte precursor cells may help overcome remyelination inhibitors and improve remyelination after transplantation into mouse brain.

Laura J. Wagstaff
Nadine Bestard-Cuche
Anna C. Williams
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Interferometric single-shot parity measurement in InAs–Al hybrid devices

A device architecture based on indium arsenide–aluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error probability of 1%.

Morteza Aghaee
Alejandro Alcaraz Ramirez
Justin Zilke
ResearchOpen Access19 Feb 2025
Nature

Volume: 638, P: 651-655
Promotion of plasma membrane repair by vitamin E

Membrane repair of myocytes is important to prevent such disease as muscular dystrophy but the properties of this repair are not well characterised. In this study, vitamin E is shown to be important in the repair of myocyte cell membranes in cultured cells and in intact muscle.

Amber C. Howard
Anna K. McNeil
Paul L. McNeil
ResearchOpen Access20 Dec 2011
Nature Communications

Volume: 2, P: 1-8
Discovery of common and rare genetic risk variants for colorectal cancer

Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

Jeroen R. Huyghe
Stephanie A. Bien
Ulrike Peters
Research03 Dec 2018
Nature Genetics

Volume: 51, P: 76-87
Erratum: The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Hans-Peter Klenk
Rebecca A. Clayton
J. Craig Venter
Amendments and CorrectionsOpen Access01 Jul 1998
Nature

Volume: 394, P: 101
Validation of three predictive models for suboptimal cytoreductive surgery in advanced ovarian cancer

Antoni Llueca
María Teresa Climent
R. Adell
ResearchOpen Access14 Apr 2021
Scientific Reports

Volume: 11, P: 1-8
Human occupation of northern Australia by 65,000 years ago

Optical dating of sediments containing stone artefacts newly excavated at Madjedbebe, Australia, indicate that human occupation began around 65,000 years ago, thereby setting a new minimum age for the arrival of people in Australia.

Chris Clarkson
Zenobia Jacobs
Colin Pardoe
Research20 Jul 2017
Nature

Volume: 547, P: 306-310
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

An adamantyl urea derivative identified as a potent bactericidal compound against Mycobacterium species and multidrug-resistant M. tuberculosis targets a late step in biogenesis of very-long-chain cell wall–bound mycolic acids—by inhibiting the transport of the fatty acids across the bacterial plasma membrane.

Anna E Grzegorzewicz
Ha Pham
Mary Jackson
Research19 Feb 2012
Nature Chemical Biology

Volume: 8, P: 334-341
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Hans-Peter Klenk
Rebecca A. Clayton
J. Craig Venter
Research27 Nov 1997
Nature

Volume: 390, P: 364-370
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

The expansion of GGGGCC repeats in the C9ORF72 gene results in the production of disease causing abnormal proteins with polymeric glycine-arginine (poly-GR) and polymeric proline-arginine (poly-PR). Here the authors demonstrate a structural mechanism of how poly-GR and poly-PR inhibit translation and how they might also perturb ribosome assembly.

Anna B. Loveland
Egor Svidritskiy
Andrei A. Korostelev
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-13
Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial

Analysis of antibody responses to COVID-19 vaccines encoding variant-specific spike, with or without ancestral spike, suggests no loss of neutralization of the ancestral virus with variant-only vaccines, which may simplify future vaccine updates.

Angela R. Branche
Nadine G. Rouphael
Elizabeth Brown
ResearchOpen Access28 Aug 2023
Nature Medicine

Volume: 29, P: 2334-2346
Optimization of cognitive assessment in Parkinsonisms by applying artificial intelligence to a comprehensive screening test

Paola Ortelli
Davide Ferrazzoli
Roberto Maestri
ResearchOpen Access11 Apr 2022
npj Parkinson's Disease

Volume: 8, P: 1-9
CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells

Sabrina Ziegler
Esther Weiss
Juergen Loeffler
ResearchOpen Access21 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease

SteatoSITE is an open resource that integrates histopathologic assessments, transcriptomic data and longitudinal electronic health records for a cohort of 940 patients with metabolic dysfunction-associated steatotic liver disease.

Timothy J. Kendall
Maria Jimenez-Ramos
Jonathan A. Fallowfield
ResearchOpen Access30 Oct 2023
Nature Medicine

Volume: 29, P: 2939-2953
Fleshy red algae mats act as temporary reservoirs for sessile invertebrate biodiversity

Comparative analyses of fleshy red algae mats and seagrass meadows highlight their value in fostering sessile invertebrate biodiversity.

Yusuf C. El-Khaled
Nauras Daraghmeh
Christian Wild
ResearchOpen Access13 Jun 2022
Communications Biology

Volume: 5, P: 1-11
Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF)

Wendy Ha
Hatice Sevim-Nalkiran
Kerrie L. McDonald
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

Cameron Kirk
Arne Küderle
Linda Van Gelder
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-23
No associations between type 1 diabetes and atopic dermatitis, allergic rhinitis, or asthma in childhood: a nationwide Danish case-cohort study

Anna Korsgaard Berg
Jannet Svensson
Steffen Ullitz Thorsen
ResearchOpen Access15 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents

Simone Kühn
Anna Mascherek
Jürgen Gallinat
ResearchOpen Access27 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis

Yanli Zhang-James
Emily C. Helminen
Stephen V. Faraone
ResearchOpen Access01 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-9
A genome-wide association study of anorexia nervosa

V Boraska
C S Franklin
C M Bulik
Research11 Feb 2014
Molecular Psychiatry

Volume: 19, P: 1085-1094
The IMAGEN study: a decade of imaging genetics in adolescents

Lea Mascarell Maričić
Henrik Walter
Amir Tahmasebi
ReviewsOpen Access29 Jun 2020
Molecular Psychiatry

Volume: 25, P: 2648-2671

Search

Mapping the genetic landscape across 14 psychiatric disorders

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function

CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents

Interferometric single-shot parity measurement in InAs–Al hybrid devices

Promotion of plasma membrane repair by vitamin E

Discovery of common and rare genetic risk variants for colorectal cancer

Erratum: The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Validation of three predictive models for suboptimal cytoreductive surgery in advanced ovarian cancer

Human occupation of northern Australia by 65,000 years ago

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial

Optimization of cognitive assessment in Parkinsonisms by applying artificial intelligence to a comprehensive screening test

CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells

An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease

Fleshy red algae mats act as temporary reservoirs for sessile invertebrate biodiversity

Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF)

Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

No associations between type 1 diabetes and atopic dermatitis, allergic rhinitis, or asthma in childhood: a nationwide Danish case-cohort study

Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents

Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis

A genome-wide association study of anorexia nervosa

The IMAGEN study: a decade of imaging genetics in adolescents

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