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Merotelic attachments allow alignment and stabilization of chromatids in meiosis II oocytes

Chromosome mis-segregation is a frequent occurrence in meiosis. Here the authors show that single unpaired chromatids avoid the spindle assembly checkpoint in the second meiotic division as they form bi-directional microtubule–kinetochore attachments, which leads to the completion of meiosis and the establishment of aneuploidy.

Anna Kouznetsova
Abrahan Hernández-Hernández
Christer Höög
Research09 Jul 2014
Nature Communications

Volume: 5, P: 1-7
Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

As oocytes age the frequency of chromosome segregation errors during meiosis I increases. Here the authors use live imaging of oocytes from naturally aged mice to provide direct evidence that bivalent separation into univalents is the primary defect responsible for age-related aneuploidy.

Yogo Sakakibara
Shu Hashimoto
Tomoya S. Kitajima
ResearchOpen Access01 Jul 2015
Nature Communications

Volume: 6, P: 1-8
A combination of the IPAG questionnaire and PiKo-6^® flow meter is a valuable screening tool for COPD in the primary care setting

Lazaros Sichletidis
Dionisios Spyratos
Anna-Bettina Haidich
Research20 May 2011
Primary Care Respiratory Journal

Volume: 20, P: 184-189
A system for inducible mitochondria-specific protein degradation in vivo

Conditional degradation of proteins is instrumental to advance our knowledge of cell biology but has been lacking for organelles like mitochondria. Here, the authors develop a proteolysis system based on the mycoplasma Lon protease that functions selectively within mitochondria in yeast and human cells.

Swastika Sanyal
Anna Kouznetsova
Camilla Björkegren
ResearchOpen Access16 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice

Anna Kouznetsova
Lisa Lister
Christer Höög
Research08 Jul 2007
Nature Genetics

Volume: 39, P: 966-968

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Merotelic attachments allow alignment and stabilization of chromatids in meiosis II oocytes

Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

A combination of the IPAG questionnaire and PiKo-6® flow meter is a valuable screening tool for COPD in the primary care setting

A system for inducible mitochondria-specific protein degradation in vivo

Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice

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A combination of the IPAG questionnaire and PiKo-6^® flow meter is a valuable screening tool for COPD in the primary care setting