Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Anna Labernadie Clear advanced filters

  • Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin–N-cadherin adherens junction promotes cancer cell invasion.

    • Anna Dart
    Research Highlights
    Nature Reviews Cancer
    Volume: 17, P: 205

  • Podosomes are actin-rich adhesion structures that show periodic oscillations in stiffness. Here, Labernadie et al.develop a method to measure the protrusion force and mechanosensing activity of individual podosomes, using an atomic force microscope and a flexible substrate membrane.

    • Anna Labernadie
    • Anaïs Bouissou
    • Isabelle Maridonneau-Parini
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro platform representing tumour/stroma interface and demonstrate how modulation by IL2 may allow immune cells to overcome stromal barriers.

    • Alice Perucca
    • Andrea Gómez Llonín
    • Anna Labernadie
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • A substantial proportion of HER2+ breast cancer patients do not benefit from HER2-targeted therapy. Here, the authors identify a population of cancer-associated fibroblasts involved in the suppression of trastuzumab-induced ADCC that can be pharmacologically targeted to raise treatment effectiveness in unresponsive tumors.

    • Elisa I. Rivas
    • Jenniffer Linares
    • Alexandre Calon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The mechanical properties of heterogeneous cell populations in colorectal tumors and the relevance to cancer metastasis remain not fully understood. Here, the authors suggest that the variations in malignant phenotypes between LGR5-positive cancer stem cells and LGR5-negative cells could be due to their distinct mechanical phenotypes observed in vitro, determined by the membrane to cortex attachment proteins Ezrin/Radixin/Moesin.

    • Sefora Conti
    • Valeria Venturini
    • Xavier Trepat
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The generation of aligned extracellular matrices by fibroblasts is shown to depend on cell reorientation following collision, leading to closer alignment of the cells’ long axes. This cell collision guidance depends on the transcription factor TFAP2C and localized regulation of actomyosin contractility.

    • Danielle Park
    • Esther Wershof
    • Erik Sahai
    Research
    Nature Materials
    Volume: 19, P: 227-238