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A CpG island-encoded mechanism protects genes from premature transcription termination

Here the authors discover that SET1 complexes function as transcription anti-termination factors that bind to CpG islands and protect low to moderately transcribed genes from the pervasive termination activity of the ZC3H4 complex.

Amy L. Hughes
Aleksander T. Szczurek
Robert J. Klose
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-19
Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction

Here, Dimitrova et al. examine how CKM–Mediator and Polycomb shape 3D chromosome interactions in ESCs and discover that gene activation during differentiation is independent of pre-formed interactions but depends on recruitment of the core Mediator.

Emilia Dimitrova
Angelika Feldmann
Robert J. Klose
ResearchOpen Access11 Oct 2022
Nature Structural & Molecular Biology

Volume: 29, P: 1000-1010
Comprehensive analysis of CNOT3-related neurodevelopmental disorders: phenotypic and genotypic characterization

Camille Engel
Michaela Rendek
Juliette Piard
Research25 Jun 2025
European Journal of Human Genetics

Volume: 33, P: 989-996

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