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Showing 1–2 of 2 results
Advanced filters: Author: Anna M Bulek Clear advanced filters

  • The T cell receptor β-chain is expressed in two isoforms, TRBC1 and TRBC2, with clonally expanded mature T cell lymphomas expressing one of them exclusively, while healthy T cells randomly express either TRBC1 or TRBC2. Here authors show structure-based design of a TRBC2-specific antibody, and depletion of malignant T cells carrying TRBC1 or TRBC2 with CAR-T cells against the cognate receptor chain in murine models.

    • Mathieu Ferrari
    • Matteo Righi
    • Martin Pule
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16