Numerous fluorescent Zn2+ sensors are available but most are unsuitable to detect physiological dynamics of cytosolic Zn2+. In this study, the authors present a genetically encoded sensor with sub-nanomolar sensitivity and show that Zn2β+βis released from endolysosomal vesicles via TRPML1 in neurons.
- Taylor F. Minckley
- Chen Zhang
- Yan Qin