Activated T cells undergo metabolic reprogramming to optimize effector functions, but the underlying mechanisms remain elusive. Here the authors show, using knockout and tumor mouse models, that deficiency of the mitochondrial protein Ant2 in T cells bypasses typical metabolic reprogramming, induces an activated-like metabolic state, and enhances T cell antitumor immunity.
- Omri Yosef
- Leonor Cohen-Daniel
- Michael Berger