Targeting virulence rather than bacterial growth is less likely to select for antibiotic resistance, but many possible targets function in both processes. Here, the authors reconstruct a genome-scale metabolic network ofP. aeruginosastrain PA14 and update that of strain PAO1, which, together with mutant screens, enable them to identify genes uniquely critical for virulence factor production.
- Jennifer A. Bartell
- Anna S. Blazier
- Jason A. Papin
