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Counting absolute number of molecules using unique molecular identifiers

Teemu Kivioja
Anna Vähärautio
Jussi Taipale
ResearchOpen Access14 Apr 2011
Nature Precedings

P: 1
Analytic framework for peptidomics applied to large-scale neuropeptide identification

Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous neuropeptides and their post-translational modifications.

Anna Secher
Christian D. Kelstrup
Jesper V. Olsen
ResearchOpen Access04 May 2016
Nature Communications

Volume: 7, P: 1-10
Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

Hans Jörg Fehling
Anna Krotkova
Harald von Boehmer
Research29 Jun 1995
Nature

Volume: 375, P: 795-798
CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure

This carefully designed study demonstrates that CagriSema overcomes metabolic adaptation in response to weight loss in rats.

Julie Mie Jacobsen
Jens Frey Halling
Rune Ehrenreich Kuhre
ResearchOpen Access08 Jul 2025
Nature Metabolism

Volume: 7, P: 1322-1329
Proteomic changes upon treatment with semaglutide in individuals with obesity

Using serum samples collected from participants of the STEP 1 and STEP 2 trials, the authors have uncovered changes to the proteome upon semaglutide treatment, which can shed light on the mechanism of action of the drug driving its benefits in obesity-related conditions.

Lasse Maretty
Dipender Gill
Milan Geybels
ResearchOpen Access03 Jan 2025
Nature Medicine

Volume: 31, P: 267-277
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

The function of proteins is often regulated by their phosphorylation at specific amino-acid residues. The authors of this article have catalogued phosphoproteins and their phosphorylation sites in 14 rat organs and tissues, and provide these data as a resource for researchers.

Alicia Lundby
Anna Secher
Jesper V. Olsen
ResearchOpen Access06 Jun 2012
Nature Communications

Volume: 3, P: 1-10
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

Marta Porniece Kumar
Anna Lena Cremer
Jens C. Brüning
ResearchOpen Access20 Dec 2021
Nature Metabolism

Volume: 3, P: 1662-1679
A genetic map of the mouse dorsal vagal complex and its role in obesity

Ludwig et al. map transcription and chromatin accessibility in single cells across the brainstem dorsal vagal complex, thereby identifying neuronal populations, including some that control feeding.

Mette Q. Ludwig
Wenwen Cheng
Tune H. Pers
Research25 Mar 2021
Nature Metabolism

Volume: 3, P: 530-545
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

In rodent models of type 2 diabetes, sustained remission of hyperglycemia can be induced by FGF1 action in the mediobasal hypothalamus. Here, the authors show that FGF1-injection is followed by marked changes in glial cell populations and that the sustained glycemic response is dependent on intact melanocortin signaling.

Marie A. Bentsen
Dylan M. Rausch
Tune H. Pers
ResearchOpen Access07 Sept 2020
Nature Communications

Volume: 11, P: 1-16
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

GDF15 has potent anti-obesity effects, but its receptor was unknown. GFRAL has now been identified as the receptor that mediates GDF15's effects via central actions in the hindbrain.

Linda Yang
Chih-Chuan Chang
Sebastian Beck Jørgensen
Research28 Aug 2017
Nature Medicine

Volume: 23, P: 1158-1166
Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review

Jacobsen, Sherr et al. evaluate the utility of novel technologies in the treatment of type 1 diabetes. Their systematic review finds technologies such as continuous glucose monitoring, insulin pumps, and decision support tools improve important measures (e.g., HbA1c, time in range, quality of life) allowing precision-directed uptake of technology.

Laura M. Jacobsen
Jennifer L. Sherr
Paul W. Franks
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-24
Counting absolute numbers of molecules using unique molecular identifiers

Unique molecular identifiers (UMIs) associate distinct sequences with every DNA or RNA molecule and can be counted after amplification to quantify molecules in the original sample. Using UMIs, the authors obtain a digital karyotype of an individual with Down's syndrome and quantify mRNA in Drosophila melanogaster cells.

Teemu Kivioja
Anna Vähärautio
Jussi Taipale
Research20 Nov 2011
Nature Methods

Volume: 9, P: 72-74
Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment

Casper Bo Gravesen Salinas
Tess Tsai-Hsiu Lu
Anna Secher
ResearchOpen Access09 Jul 2018
Scientific Reports

Volume: 8, P: 1-12

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