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Showing 1–3 of 3 results
Advanced filters: Author: Annamaria Tessitore Clear advanced filters

  • Authors report that long-term intestinal tissue maintenance in naked mole rats is achieved by having an expanded pool of slow-dividing adult stem cells while a higher proportion of differentiated cells confer enhanced function and protection to the intestinal mucosa.

    • Shamir Montazid
    • Sheila Bandyopadhyay
    • Shazia Irshad
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to structurally characterize TMEM16K and show that it is an ER-resident lipid scramblase.

    • Simon R. Bushell
    • Ashley C. W. Pike
    • Elisabeth P. Carpenter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The cryo-EM structure of human polycystin-2 (PC2) in a closed conformation reveals a domain located above the pore filter, forming an upper vestibule and making contacts with the pore and voltage-sensor-like domains.

    • Mariana Grieben
    • Ashley C W Pike
    • Elisabeth P Carpenter
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 114-122