Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Anne Krogsdam Clear advanced filters

  • Efficacy of chimeric antigen receptor (CAR)-T in solid tumors are limited by the antigen heterogeneity and tumor microenvironment (TME) induced exhaustion. The authors here manifested that Nr2f6-deficient CAR-T cells have superior anti-tumor effect compared with traditional CAR-T cells, which is associated with enhanced cytotoxic function, followed by durable response due to epitope spreading.

    • Dominik Humer
    • Victoria Klepsch
    • Gottfried Baier
    ResearchOpen Access
    Nature Communications
    P: 1-20

  • The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evolution.

    • Mirjana Efremova
    • Dietmar Rieder
    • Zlatko Trajanoski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Immune checkpoints blockade (ICB) is a viable anti-cancer strategy. Here the authors show that nuclear receptor NR2F6 acts as an immune checkpoint in T cells and, using mouse models and human T cells, they show NR2F6 inhibition might improve current ICB therapy or work as an alternative therapeutic strategy.

    • Victoria Klepsch
    • Natascha Hermann-Kleiter
    • Gottfried Baier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13