Nature Search

TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation

Some brain lesions recover in multiple sclerosis, while others do not; however, the underlying mechanisms are unclear. Here, the authors show that microglia-derived TGFα orchestrates immune control and tissue repair, and that intranasal delivery of TGFα in the autoimmune encephalomyelitis model promotes lesion resolution.

Lena Lößlein
Mathias Linnerbauer
Veit Rothhammer
ResearchOpen Access19 Jun 2025
Nature Communications

Volume: 16, P: 1-17
INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas

Manchado and colleagues combine CRISPR screening and transcriptomics to identify INPP5A as a dependency and therapeutic target in uveal melanoma driven by mutations in GNAQ/GNA11 and show that IP4 levels correlate with sensitivity to INPP5A loss.

Ahmed M. O. Elbatsh
Ali Amin-Mansour
Eusebio Manchado
ResearchOpen Access17 Jan 2024
Nature Cancer

Volume: 5, P: 481-499
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology

Linnerbauer and colleagues find that HB-EGF produced by reactive astrocytes is protective during autoimmune neuroinflammation, but epigenetically suppressed during late stages.

Mathias Linnerbauer
Lena Lößlein
Veit Rothhammer
ResearchOpen Access26 Feb 2024
Nature Immunology

Volume: 25, P: 432-447
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

Abnormal cytoplasmic aggregates of FUS are a hallmark of some forms of amyotrophic lateral sclerosis (ALS). Here, using neurons derived from patients with FUS-ALS, the authors demonstrate that impairment of PARP-dependent DNA damage signaling is an event that occurs upstream of neurodegeneration and cytoplasmic aggregate formation in FUS-ALS.

Marcel Naumann
Arun Pal
Andreas Hermann
ResearchOpen Access23 Jan 2018
Nature Communications

Volume: 9, P: 1-17
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

Co-inhibitory signaling controls immune mechanisms in health and disease. The authors here show that in autoimmune neuroinflammation, astrocytic PD-L1 mitigates autoimmune neuroinflammation through interaction with PD1 expressing microglia.

Mathias Linnerbauer
Tobias Beyer
Veit Rothhammer
ResearchOpen Access09 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour

During cell division, a cytoplasmic bridge—the midbody—forms between the nascent daughter cells, but it has been unclear under which conditions this is retained by a daughter cell or released. Now, Ettinger and colleagues show that midbody-release occurs more frequently in stem cells compared with cancer cells.

Andreas W. Ettinger
Michaela Wilsch-Bräuninger
Wieland B. Huttner
ResearchOpen Access18 Oct 2011
Nature Communications

Volume: 2, P: 1-12
DEL-1 promotes macrophage efferocytosis and clearance of inflammation

DEL-1 protein interferes with leukocyte adhesion to prevent inflammation. Chavakis and colleagues now show that DEL-1 contributes to tissue resolution after inflammation by promoting macrophage-mediated efferocytosis and M2-like pro-resolving activities.

Ioannis Kourtzelis
Xiaofei Li
Triantafyllos Chavakis
Research19 Nov 2018
Nature Immunology

Volume: 20, P: 40-49
Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

Natalia Traissard
Karine Herbeaux
Jean-Christophe Cassel
Research07 Jun 2006
Neuropsychopharmacology

Volume: 32, P: 851-871
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller et al. provide a comprehensive resource depicting cellular substrates, localization and interacting partners of RhoGEF and RhoGAP proteins regulating the canonical Rho family of GTPases.

Paul M. Müller
Juliane Rademacher
Oliver Rocks
Research23 Mar 2020
Nature Cell Biology

Volume: 22, P: 498-511
Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis: A retrospective analysis of the DRST and GREM registries

Johannes Lübke
Deborah Christen
Jens Panse
ResearchOpen Access06 Mar 2024
Leukemia

Volume: 38, P: 810-821
TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model

Robin Scharrenberg
Melanie Richter
Froylan Calderon de Anda
ResearchOpen Access19 Sept 2022
Molecular Psychiatry

Volume: 27, P: 4707-4721
A complex of Neuroplastin and Plasma Membrane Ca²⁺ ATPase controls T cell activation

Mark Korthals
Kristina Langnaese
Ulrich Thomas
ResearchOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling

Roman N. Rodionov
Natalia Jarzebska
Norbert Weiss
ResearchOpen Access07 Jun 2022
Scientific Reports

Volume: 12, P: 1-13
A blueprint for integrating scientific approaches and international communities to assess basin-wide ocean ecosystem status

Capacity building and engagement are crucial to support science-led sustainable ocean policies that are integrated, interdisciplinary and internationally collaborative as well as being effective at a range of temporal and spatial scales.

J. Murray Roberts
Colin W. Devey
Lea-Anne Henry
ReviewsOpen Access19 Jan 2023
Communications Earth & Environment

Volume: 4, P: 1-9

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