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Advanced filters: Author: Anne-Mette Bornhardt Hedegaard Clear advanced filters

  • ErbB signalling is stimulated by the release of its ligands from the cell surface through metalloproteinase-dependent cleavage. Dombernowsky et al. show that this process is controlled by the sorting protein PACS-2, which enhances ErbB ligand release by regulating trafficking of the metalloprotease ADAM17.

    • Sarah Louise Dombernowsky
    • Jacob Samsøe-Petersen
    • Marie Kveiborg
    Research
    Nature Communications
    Volume: 6, P: 1-13