The voltage-gated calcium channel protein subunit α2δ is shown to control both the abundance of voltage-gated calcium channels and their coupling to the vesicular release of neurotransmitters into the synapse; because the α2δ family is a known target of potent analgesics, this study offers a new link between basic synaptic physiology and pain research in the clinic.
- Michael B. Hoppa
- Beatrice Lana
- Timothy A. Ryan
