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A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Rationally designed laterally-condensed-catalysts deliver robust activity and selectivity for ethylene production in acetylene hydrogenation

The selective hydrogenation of trace acetylene to ethylene is a well-established process for purifying fossil-derived ethylene streams. Here, the authors present a self-repairing Pd-C laterally condensed catalyst that improves selectivity, prevents sub-surface hydride formation, and achieves high ethylene productivity, effectively bridging the gap between powder catalysts and single-crystal model catalysts.

Zehua Li
Eylül Öztuna
Robert Schlögl
ResearchOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-13
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Thijn R. Brummelkamp
Sebastian M. B. Nijman
René Bernards
Research14 Aug 2003
Nature

Volume: 424, P: 797-801
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

Pooled and sex-specific genome-wide association analyses identify new risk loci for restless legs syndrome and candidates for drug repurposing. Machine learning models combining genetic and other information show improved risk prediction performance.

Barbara Schormair
Chen Zhao
Juliane Winkelmann
ResearchOpen Access05 Jun 2024
Nature Genetics

Volume: 56, P: 1090-1099
Measuring the atomic spin-flip scattering rate by x-ray emission spectroscopy

Régis Decker
Artur Born
Alexander Föhlisch
ResearchOpen Access20 Jun 2019
Scientific Reports

Volume: 9, P: 1-6
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

TGF-β signaling is commonly aberrantly activated in gliomas and other tumors and can exert a pro-oncogenic function. The authors identify a new mechanism for upregulation of TGF-β signaling in cancer. The deubiquitinase USP15 is shown to be able to bind the TGF-β receptor complex, counteract its degradation and potentiate its stimulation of downstream mediators. USP15 is amplified in human glioblastoma and could represent a therapeutic target, as its downregulation impairs the growth of glioblastoma cells in vivo.

Pieter J A Eichhorn
Laura Rodón
Joan Seoane
Research19 Feb 2012
Nature Medicine

Volume: 18, P: 429-435
Mechanical regulation of glycolysis via cytoskeleton architecture

Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.

Jin Suk Park
Christoph J. Burckhardt
Gaudenz Danuser
Research12 Feb 2020
Nature

Volume: 578, P: 621-626

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A saturated map of common genetic variants associated with human height

Rationally designed laterally-condensed-catalysts deliver robust activity and selectivity for ethylene production in acetylene hydrogenation

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

Measuring the atomic spin-flip scattering rate by x-ray emission spectroscopy

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

Mechanical regulation of glycolysis via cytoskeleton architecture

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