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Showing 1–3 of 3 results
Advanced filters: Author: Annette N D Scharf Clear advanced filters

  • Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

    • Andrew D. Grotzinger
    • Josefin Werme
    • Jordan W. Smoller
    ResearchOpen Access
    Nature
    Volume: 649, P: 406-415

  • Small heat shock proteins (sHsps) contribute to cellular recovery and survival following stress causing elevated levels of misfolded or unfolded proteins. Here the authors demonstrate that sHsps function by maintaining aggregating proteins in close-to-native conformations to facilitate chaperone-mediated refolding.

    • Sophia Ungelenk
    • Fatemeh Moayed
    • Bernd Bukau
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.

    • Mirko C Sobotta
    • Willy Liou
    • Tobias P Dick
    Research
    Nature Chemical Biology
    Volume: 11, P: 64-70