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Showing 1–4 of 4 results

Advanced filters: Author: Annick You-Ten Clear advanced filters

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression

The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell proliferation and autoimmunity.

Zhenyue Hao
Yi Sheng
Tak W. Mak
ResearchOpen Access13 Jan 2017
Nature Communications

Volume: 8, P: 1-14
ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

ARIH2 is a RING-between-RING E3 ligase. Pellegrini and colleagues show that ARIH2 is needed to limit excessive NF-κB signaling in DCs. Loss of ARIH2 is associated with embryonic death due to excessive inflammatory responses.

Amy E Lin
Gregor Ebert
Marc Pellegrini
Research25 Nov 2012
Nature Immunology

Volume: 14, P: 27-33
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation are described, in a new model that should help in investigating the links between mutant IDH1 and leukaemia.

Masato Sasaki
Christiane B. Knobbe
Tak W. Mak
Research04 Jul 2012
Nature

Volume: 488, P: 656-659
The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer

Christian Bassi
Jerome Fortin
Tak W. Mak
ResearchOpen Access31 May 2021
Cell Death & Differentiation

Volume: 28, P: 3036-3051