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Showing 1–3 of 3 results
Advanced filters: Author: Annie Delaunois Clear advanced filters

  • FLuID enables privacy-preserving knowledge sharing in drug discovery using knowledge distillation. The results show that the approach expands applicability domains and fosters collaboration across organizations without compromising data privacy or security.

    • Thierry Hanser
    • Ernst Ahlberg
    • Tomoya Yukawa
    Research
    Nature Machine Intelligence
    Volume: 7, P: 423-436

  • Secondary pharmacology screening of investigational small-molecule drugs for potentially adverse off-target activities is now standard practice in pharmaceutical research and development. This article uses a survey across 18 companies as the basis for discussing strategies for implementing secondary pharmacology screening programmes, approaches for interpreting off-target activities and which targets to include in screening panels, including several targets not commonly included in existing panels.

    • Richard J. Brennan
    • Stephen Jenkinson
    • Jean-Pierre Valentin
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 525-545