Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Annika Wefers Clear advanced filters

  • Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiation state and clinical outcome.

    • Philipp Jurmeister
    • Stefanie Glöß
    • David Capper
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Simultaneous activation of Wnt and Shh pathways in murine neural precursor cells results in the formation of embryonal tumors with multilayered rosettes (ETMR) that recapitulate the histological and molecular features of human tumors. This novel mouse model represents a platform for evaluating therapeutic approaches for this rare malignant pediatric brain tumor, and provides novel insights into the cell of origin and molecular mechanisms driving the disease.

    • Julia E Neumann
    • Annika K Wefers
    • Ulrich Schüller
    Research
    Nature Medicine
    Volume: 23, P: 1191-1202

  • Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

    • Christian Koelsche
    • Daniel Schrimpf
    • Andreas von Deimling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The integration of DNA methylation profiling and targeted sequencing with neuropathology improves the diagnostic accuracy of central nervous system tumors in a population-based cohort of more than 1,200 newly diagnosed pediatric patients.

    • Dominik Sturm
    • David Capper
    • David. T. W. Jones
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 917-926

  • A neural epigenetic signature detectable via plasma analyses is prognostic in patients with glioblastoma, resembling an oligodendrocyte-progenitor- and neuronal-progenitor-cell-like state and showing increased neuro-to-glioma synapse formation.

    • Richard Drexler
    • Robin Khatri
    • Franz L. Ricklefs
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 1622-1635

  • An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

    • David Capper
    • David T. W. Jones
    • Stefan M. Pfister
    Research
    Nature
    Volume: 555, P: 469-474