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MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways

Understanding the organism-wide molecular effects of spaceflight becomes increasingly critical as space exploration accelerates. Here, the authors show that miRNAs mediate microgravity-induced adaptations via extracellular matrix, DNA damage and developmental pathways, as shown by small RNA profiling in 13 organs of mice during and after spaceflight.

Friederike Grandke
Shusruto Rishik
Andreas Keller
ResearchOpen Access05 Feb 2026
Nature Communications

Volume: 17, P: 1-17
Environmental decision neuroscience connects the brain to climate action

Climate change is driven by individual behaviour, yet little is known about how people make environmental choices. Environmental decision neuroscience examines the neural processes behind consequential climate-relevant decisions, and has revealed three core mechanisms that are beginning to crystallize as central to sustainable action.

Daria Knoch
Annika M. Wyss
Comments & Opinion21 Jan 2026
Nature Reviews Neuroscience

Volume: 27, P: 151-152
Large but diminishing effects of climate action nudges under rising costs

Berger et al. investigate green defaults under varying prices. Using field data from a flight compensation platform, they show that green defaults are effective. Their effectiveness, however, vanishes when costs become too high.

Sebastian Berger
Andreas Kilchenmann
Annika M. Wyss
Research23 Jun 2022
Nature Human Behaviour

Volume: 6, P: 1381-1385
A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

MicroRNAs regulate brain development and aging. Here, authors show that a spatio-temporal atlas of 15 mouse brain regions reveals sex- and region-specific microRNA patterns, including age-related microglial miR-155-5p increase targeting mTOR.

Annika Engel
Viktoria Wagner
Andreas Keller
ResearchOpen Access17 May 2025
Nature Communications

Volume: 16, P: 1-17
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

An atlas of noncoding RNA in aging and rejuvenated mice identifies a set of deregulated miRNAs.

Viktoria Wagner
Fabian Kern
Andreas Keller
ResearchOpen Access27 Apr 2023
Nature Biotechnology

Volume: 42, P: 109-118
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

A microglial state, featuring lipid droplets and secretion of neurotoxic factors, is shown to be most prominent in people with Alzheimer’s disease who have the APOE4 genotype.

Michael S. Haney
Róbert Pálovics
Tony Wyss-Coray
ResearchOpen Access13 Mar 2024
Nature

Volume: 628, P: 154-161
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

Annika Wyss
Tina Raselli
Benjamin Misselwitz
ResearchOpen Access11 Feb 2019
Mucosal Immunology

Volume: 12, P: 733-745

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MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways

Environmental decision neuroscience connects the brain to climate action

Large but diminishing effects of climate action nudges under rising costs

A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

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