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Showing 1–2 of 2 results
Advanced filters: Author: Anouk Ewen Clear advanced filters

  • Follicular and marginal zone B (FoB and MZB, respectively) cells have divergent metabolic characteristics. Here the authors show that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, differentially impacts FoB and MZB homeostasis, while specifically impeding FoB activation and downstream antiviral immunity.

    • Davide G. Franchina
    • Henry Kurniawan
    • Dirk Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Itaconate is an immunomodulatory macrophage metabolite. Mesaconate, a structurally similar molecule, is shown to be synthesized from itaconate in inflammatory macrophages and shows similar immunomodulatory effects, despite not repressing tricarboxylic acid cycle activity nor inhibiting succinate dehydrogenase activity.

    • Wei He
    • Antonia Henne
    • Karsten Hiller
    Research
    Nature Metabolism
    Volume: 4, P: 524-533