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  • Here, Nathalie Rommel, Jan Tack and colleagues provide an overview of the extensive literature concerning globus and discuss the quality of the evidence to date. They also put forward a potential theoretical model to support management and future research in globus.

    • Margot Selleslagh
    • Lukas van Oudenhove
    • Nathalie Rommel
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 220-233

  • Up to 30% of patients with typical GERD symptoms are refractory to standard acid-suppressive treatment. In this Review, the authors discuss the clinical features and current management of patients with refractory GERD, and the roles of surgical interventions and pharmaceutical agents. Finally, the authors provide up-to-date algorithms for the optimal management of patients with refractory GERD.

    • Emidio Scarpellini
    • Daphne Ang
    • Jan Tack
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 13, P: 281-294