The embryonic development of forelimbs and hindlimbs is regulated by transcription factors, including Pitx1, Tbx4 and Tbx5. In this study, the contributions of Tbx4 and Tbx5 to limb identity are further delineated, resulting in the demonstration of a role for Tbx4 in hindlimb skeletal and muscle patterning.
- Jean-François Ouimette
- Marisol Lavertu Jolin
- Jacques Drouin
