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Showing 1–2 of 2 results
Advanced filters: Author: Anthony Marelli Clear advanced filters

  • Bill et al describe two high-throughput methods to detect protein-protein interactions in cells in real-time using the split-NanoLuciferase-complementation system. They demonstrate the methods can detect exogenously (RT-bind) or endogenously (EndoBind) expressed proteins, respectively.

    • Anke Bill
    • Sheryll Espinola
    • Frederick J. King
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-6

  • One of the major obstacles in nanoparticle-based therapy is to achieve tumour targeting, limiting non-specific accumulation of the nanoparticles. Here the authors propose the conjugation of anti-HER2 scFv fragments to the silica nanoparticles, increasing specificity and limiting the final size of the immunoconjugates below the renal clearance threshold.

    • Feng Chen
    • Kai Ma
    • Michelle S. Bradbury
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11