For DNA replication to proceed through heterochromatin, the replication machinery must negotiate the highly condensed chromatin. A new study shows that an ACF1–ISWI chromatin remodeling complex is required for the replication of pericentromeric heterochromatin. This complex may act to unravel chromatin structure in these regions of the genome, thereby permiting movement of the replication fork.
- Ivana L. de la Serna
- Anthony N. Imbalzano
