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Showing 1–4 of 4 results
Advanced filters: Author: Anthony O. Omole Clear advanced filters

  • USP18 is a multifunctional cysteine protease involved in IFN pathways. Here, the authors report chemical probes and chemoproteomics platforms that allow to detect and perturb USP18 activity in complex biological systems with the potential to unravel important (de)ISGylation-dependent processes.

    • Griffin J. Davis
    • Anthony O. Omole
    • Euna Yoo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Current treatment options for ovarian cancer are limited to surgery and chemotherapy, but most patients experience recurrent metastatic diseases. Here, the authors develop an antigen–adjuvant combination immunotherapy for ovarian cancer by coupling tumor antigen loaded liposomes with plant virus adjuvant as a vaccine platform to prevent cancer recurrence and metastatic diseases.

    • Zhongchao Zhao
    • Debbie K. Ledezma
    • Nicole F. Steinmetz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Virus nanotechnology can be exploited for intratumoural immunotherapy. This Review discusses the clinical and preclinical landscape of viruses and virus-like particles as tools and carrier vehicles for intratumoural immunotherapy.

    • Anthony O. Omole
    • Zhongchao Zhao
    • Nicole F. Steinmetz
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 916-929

  • Studies of cowpea mosaic virus (CPMV) reveals safety and non-pathogenicity of drug candidate in mammalian cells, bolstering support for intratumoral immunotherapy clinical translation.

    • Anthony O. Omole
    • Jessica Fernanda Affonso de Oliveira
    • Nicole F. Steinmetz
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-13