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Showing 1–12 of 12 results
Advanced filters: Author: Anthony P Weetman Clear advanced filters

  • Although medication for Graves' hyperthyroidism can be withdrawn without adverse effects for the patient, the data regarding the optimal duration of therapy are still unsatisfactory. This Viewpoint discusses how long treatment for Graves' disease should be continued and how withdrawal of antithyroid drugs might affect remission and relapse.

    • Anthony P Weetman
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 2-3

  • Richard Spritz and colleagues identify variants on 3p13 and 6q27 associated with generalized vitiligo, a common autoimmune disorder with loss of melanocytes and depigmentation.

    • Ying Jin
    • Stanca A Birlea
    • Richard A Spritz
    Research
    Nature Genetics
    Volume: 42, P: 576-578

  • Thyroid stimulation in Graves disease is caused by antibodies to the TSH receptor that have thyroid-stimulating or thyroid-blocking activity. Antibody detection can aid diagnosis and prediction of outcomes of the disease, as well as prediction of the course of associated ophthalmology. In this Review, Ajjan and Weetman describe the different measurement techniques available and their clinical applications.

    • RA Ajjan
    • AP Weetman
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 4, P: 461-468

  • The complex relationship between pregnancy and thyroid function, and its clinical effect on mother and baby, continued to stimulate research in 2011. Key advances were made on three important issues: how long maternal thyroid function affects fetal thyroid hormone levels; whether thyroid autoimmunity affects pregnancy outcome; and the prevalence of permanent hypothyroidism after postpartum thyroiditis.

    • Anthony P. Weetman
    News & Views
    Nature Reviews Endocrinology
    Volume: 8, P: 69-70

  • Pregnancy is an immunological balancing act in which major changes in the mother's immune system occur that prevent rejection of the fetus that bears paternal antigens. This Review discusses the immunological mechanisms involved in such tolerance of the fetus, and highlights how these mechanisms may explain the clinical changes in autoimmune thyroid disease during and after pregnancy.

    • Anthony P. Weetman
    Reviews
    Nature Reviews Endocrinology
    Volume: 6, P: 311-318

  • Richard Spritz and colleagues report genome-wide association analyses identifying 13 new susceptibility loci for generalized vitiligo. Their functional pathway analysis shows that many vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components.

    • Ying Jin
    • Stanca A Birlea
    • Richard A Spritz
    Research
    Nature Genetics
    Volume: 44, P: 676-680

  • Graves' disease and other autoimmune syndromes affecting the thyroid are the archetypes of organ-specific autoimmunity. Despite intensive research, the relative contribution of genetic and environmental factors to disease pathogenesis is not clear. Here, the latest developments in understanding the determinants of these diseases are discussed.

    • Anthony P. Weetman
    News & Views
    Nature Immunology
    Volume: 2, P: 769-770

  • Richard Spritz and colleagues present a genome-wide association study of autoimmune vitiligo in 4,680 cases and 39,586 controls and report 23 new risk loci. Their results highlight specific pathways, including immune response, apoptosis and melanocyte function, that may be important in the pathobiology of autoimmune vitiligo.

    • Ying Jin
    • Genevieve Andersen
    • Richard A Spritz
    Research
    Nature Genetics
    Volume: 48, P: 1418-1424

  • Medically not yet explained symptoms (MNYES) are an important consideration in patients treated for hypothyroidism who experience persistent symptoms. This Perspective brings attention to the issue of MNYES in hypothyroidism and considers effective management.

    • Laszlo Hegedüs
    • Christina M. Van Der Feltz-Cornelis
    • Petros Perros
    Reviews
    Nature Reviews Endocrinology
    Volume: 20, P: 685-693

  • Treatment of primary hypothyroidism is improving but many patients still report a reduced quality of life compared with healthy individuals. This Review discusses the management of primary hypothyroidism and the potential reasons for patient dissatisfaction with treatment.

    • Laszlo Hegedüs
    • Antonio C. Bianco
    • Petros Perros
    Reviews
    Nature Reviews Endocrinology
    Volume: 18, P: 230-242