Nature Search

Personalization of therapy and polypills

Ruth Webster
Anthony Rodgers
Correspondence18 Mar 2014
Nature Reviews Cardiology

Volume: 11, P: 307
Hypoglycemia and Maple Syrup Urine Disease: Defective Gluconeogenesis

Morey W Haymond
Irene E Karl
Anthony S Pagliara
Research01 May 1973
Pediatric Research

Volume: 7, P: 500-508
Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial

In the phase 2 PASSPORT study, treatment with the anti-tau antibody gosuranemab did not show clinical benefit in participants with supranuclear palsy, suggesting that N-terminal tau neutralization does not translate into clinical efficacy.

Tien Dam
Adam L. Boxer
Samantha Budd Haeberlein
Research12 Aug 2021
Nature Medicine

Volume: 27, P: 1451-1457
Author Correction: Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease

Anubha Agarwal
Priya M. Mehta
Mark D. Huffman
Amendments and Corrections17 Jun 2024
Nature Medicine

Volume: 30, P: 2371
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
Coronary artery calcium and polypill therapy

Controversy surrounds the use of polypills in the primary prevention of cardiovascular disease, particularly in relation to which individuals should be targeted for treatment. Coronary artery calcium imaging has been presented as being of potential benefit in excluding those who are least likely to benefit from such treatment.

Ruth Webster
Anthony Rodgers
News & Views26 Nov 2013
Nature Reviews Cardiology

Volume: 11, P: 7-8
The effect of salt substitution on frequency and severity of headache: results from the SSaSS cluster-randomised controlled trial of 20,995 participants

Faraidoon Haghdoost
Sonali R. Gnanenthiran
Anthony Rodgers
ResearchOpen Access24 Feb 2024
European Journal of Clinical Nutrition

Volume: 78, P: 401-406
Quantum sensing for gravity cartography

A study reports a quantum gravity gradient sensor with a design that eliminates the need for long measurement times, and demonstrates the detection of an underground tunnel in an urban environment.

Ben Stray
Andrew Lamb
Michael Holynski
ResearchOpen Access23 Feb 2022
Nature

Volume: 602, P: 590-594
An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

A F Jorm
A S Henderson
S Easteal
Research28 Sept 1998
Molecular Psychiatry

Volume: 3, P: 449-451
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study

A systematic review using the burden of proof meta-analytic method found a significant harmful effect between high systolic blood pressure and ischemic heart disease.

Christian Razo
Catherine A. Welgan
Gregory A. Roth
ResearchOpen Access10 Oct 2022
Nature Medicine

Volume: 28, P: 2056-2065
Geographical migration and fitness dynamics of Streptococcus pneumoniae

Mathematical modelling of 15 years of data from South Africa reveals the spread and vaccine-driven changes in fitness and antimicrobial resistance of Streptococcus pneumoniae.

Sophie Belman
Noémie Lefrancq
Henrik Salje
ResearchOpen Access03 Jul 2024
Nature

Volume: 631, P: 386-392
Reduced efficacy of blood pressure lowering drugs in the presence of diabetes mellitus—results from the TRIUMPH randomised controlled trial

Sonali R. Gnanenthiran
Ruth Webster
Vipin Jose
Research14 Oct 2022
Hypertension Research

Volume: 46, P: 128-135
The contribution of de novo coding mutations to autism spectrum disorder

Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to the incidence of simplex autism, with target genes in affected females overlapping those in males of lower but not higher IQ; targets also overlap known targets for intellectual disability and schizophrenia, and are enriched for chromatin modifiers, FMRP-associated genes and embryonically expressed genes.

Ivan Iossifov
Brian J. O’Roak
Michael Wigler
Research29 Oct 2014
Nature

Volume: 515, P: 216-221
Comprehensive molecular profiling of lung adenocarcinoma

An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

Eric A. Collisson
Joshua D. Campbell
Ming-Sound Tsao
ResearchOpen Access09 Jul 2014
Nature

Volume: 511, P: 543-550
Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

The Aurora kinases orchestrate chromosome segregation and cell division. Zeeshan et al. studied divergent Plasmodium ARK2 and EB1 using live cell imaging, proteomics and functional genetics. These are critical components for atypical spindle dynamics during transmission stages.

Mohammad Zeeshan
Edward Rea
Rita Tewari
ResearchOpen Access13 Sept 2023
Nature Communications

Volume: 14, P: 1-19
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

Eleanor Barnes
Carl S. Goodyear
Deborah Richardson
ResearchOpen Access06 Jul 2023
Nature Medicine

Volume: 29, P: 1760-1774
Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease

In an updated systematic review and meta-analysis, fixed-dose combination therapy using a polypill with at least one blood pressure-lowering drug and one lipid-lowering drug was found to reduce both incident cardiovascular disease and all-cause mortality.

Anubha Agarwal
Priya M. Mehta
Mark D. Huffman
Research26 Mar 2024
Nature Medicine

Volume: 30, P: 1199-1209
Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ

This study highlights the impact of the gut virome on host immunity by showing that a specific strain of murine astrovirus in the gut of immunodeficient mice protects them against norovirus and rotavirus infections, and that this protection depends on interferon-λ signalling in gut epithelial cells.

Harshad Ingle
Sanghyun Lee
Megan T. Baldridge
Research01 Apr 2019
Nature Microbiology

Volume: 4, P: 1120-1128
Polypills for the prevention of cardiovascular disease: a framework for wider use

Combinations of cardiovascular medications taken in a single pill — known as polypills — are effective but not widely used, requiring a global shift from physicians, regulators and drug developers.

Anushka Patel
Dike Ojji
Anthony Rodgers
Comments & Opinion31 Jan 2022
Nature Medicine

Volume: 28, P: 226-229
Hypertension

Systemic arterial hypertension is the most important risk factor for morbidity and mortality worldwide and the most common modifiable risk factor for cardiovascular disease. It is important to assess a person's predicted cardiovascular risk in addition to the level of blood pressure in making treatment decisions.

Suzanne Oparil
Maria Czarina Acelajado
Paul K. Whelton
Reviews22 Mar 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-21
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of adipose S-adenosylmethionine and NAD⁺, rendering Nnmt a novel target for treating obesity and type 2 diabetes.

Daniel Kraus
Qin Yang
Barbara B. Kahn
Research09 Apr 2014
Nature

Volume: 508, P: 258-262
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Amendments and Corrections17 Jul 2020
Nature Biotechnology

Volume: 38, P: 1000
A Bayesian framework for deriving sector-based methane emissions from top-down fluxes

Sector-based methane emissions can be backed out from observed methane fluxes, using a Bayesian optimal estimation method. This could help with monitoring gas leaks from industry.

Daniel H. Cusworth
A. Anthony Bloom
John R. Worden
ResearchOpen Access25 Nov 2021
Communications Earth & Environment

Volume: 2, P: 1-8
Docetaxel-carboplatin as first line chemotherapy for epithelial ovarian cancer

P A Vasey
R Atkinson
S B Kaye
ResearchOpen Access16 Jan 2001
British Journal of Cancer

Volume: 84, P: 170-178
A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch syndrome

Tomer Adar
Linda H Rodgers
Daniel C Chung
Research06 Jan 2017
Modern Pathology

Volume: 30, P: 440-447
Wisdom of the Crowd: insights gained from comparing predicted and observed effects of blood pressure lowering strategies

In a first of its kind assessment in cardiovascular research, we assessed whether pooled cardiovascular expertise could accurately predict efficacy and tolerability for both a novel and an established treatment option. A survey was administered prior to the publication of the QUARTET (A Quadruple UltrA-low-dose tReatment for hypErTension) trial. QUARTET was a multicentre, double-blind, parallel-group, trial that randomised participants to initial treatment with either monotherapy or an ultra-low dose quadruple single pill combination for 12 weeks. Survey participants were asked to predict blood pressure (BP) at 12 weeks and 52 weeks for both groups.

Sonali R. Gnanenthiran
Vivekanand Jha
Anthony Rodgers
ResearchOpen Access11 Apr 2023
Journal of Human Hypertension

Volume: 37, P: 422-424
Participants’ views of ultra-low dose combination therapy for high blood pressure: a mixed-methods study from the QUARTET trial

Joshua G. Kovoor
Clara K. Chow
Emily R. Atkins
ResearchOpen Access14 May 2024
Journal of Human Hypertension

Volume: 38, P: 516-522
The contribution of sodium reduction and potassium increase to the blood pressure lowering observed in the Salt Substitute and Stroke Study

Liping Huang
Qiang Li
Bruce Neal
ResearchOpen Access21 Feb 2024
Journal of Human Hypertension

Volume: 38, P: 298-306
Prescription and dispensing duration of medicines for hypertension and other chronic conditions: a review of international policies and evidence to inform the Australian setting

Peder af Geijerstam
Michael O. Falster
Aletta E. Schutte
ReviewsOpen Access07 Jun 2024
Hypertension Research

Volume: 47, P: 2104-2114
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

Danielle Nettere
Shakthi Unnithan
Justin Pollara
ResearchOpen Access24 Nov 2023
npj Vaccines

Volume: 8, P: 1-15
Cost-effectiveness analysis of initial treatment with single-pill combination antihypertensive medications

Alexis S. Bryan
Andrew E. Moran
Brandon K. Bellows
Research15 Feb 2023
Journal of Human Hypertension

Volume: 37, P: 985-992
A digital health intervention for cardiovascular disease management in primary care (CONNECT) randomized controlled trial

Julie Redfern
Genevieve Coorey
David Peiris
ResearchOpen Access10 Sept 2020
npj Digital Medicine

Volume: 3, P: 1-9
Associations between body mass index and the risk of renal events in patients with type 2 diabetes

Kamel Mohammedi
John Chalmers
Mark Woodward
ResearchOpen Access17 Jan 2018
Nutrition & Diabetes

Volume: 8, P: 1-9
Leveraging antigenic seniority for maternal vaccination to prevent mother-to-child transmission of HIV-1

Ashley N. Nelson
Maria Dennis
Sallie R. Permar
ResearchOpen Access30 Jul 2022
npj Vaccines

Volume: 7, P: 1-13
Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders

Shlomo Yeshurun
Anthony J. Hannan
Reviews08 Mar 2018
Molecular Psychiatry

Volume: 24, P: 536-548
Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

Zeeshan et al. used real-time live-cell and ultrastructural imaging, conditional gene knockdown, RNA-seq and proteomic approaches to implicate Plasmodium PP1 in both mitotic exit and, potentially, establishing cell polarity during zygote development in the mosquito midgut. They suggest that small molecule inhibitors of PP1 should be explored for blocking parasite transmission.

Mohammad Zeeshan
Rajan Pandey
Rita Tewari
ResearchOpen Access18 Jun 2021
Communications Biology

Volume: 4, P: 1-14
Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development

Ekta Saini
Mohammad Zeeshan
Rita Tewari
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Correspondence18 Jun 2020
Nature Biotechnology

Volume: 38, P: 927-931

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