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Showing 1–20 of 20 results
Advanced filters: Author: Antoine R Adamantidis Clear advanced filters
  • On the anniversary of the Boyden et al. (2005) paper that introduced the use of channelrhodopsin in neurons, Nature Neuroscience asks selected members of the community to comment on the utility, impact and future of this important technique.

    • Antoine Adamantidis
    • Silvia Arber
    • Rachel I Wilson
    Comments & Opinion
    Nature Neuroscience
    Volume: 18, P: 1202-1212
  • The extent to which the sleeping brain can discern safety from danger is poorly understood. In mice, the authors show that centro-medial thalamic neurons detect threat-related sounds and selectively trigger awakenings during NREM, but not REM, sleep.

    • Ida Luisa Boccalaro
    • Mattia Aime
    • Antoine Adamantidis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • A multimodal fiber can both record and manipulate neural activity in mice.

    • Carolina Gutierrez Herrera
    • Antoine R Adamantidis
    News & Views
    Nature Biotechnology
    Volume: 33, P: 259-260
  • Understanding the sudden regime shifts leading to epileptic seizures is crucial for developing preventive measures. This research reveals that subtle dynamical changes can indicate impending seizures, and highlights the effectiveness of active probing over passive recording in assessing neural excitability in hippocampal circuits.

    • Gregory Lepeu
    • Ellen van Maren
    • Maxime O. Baud
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • The authors find that optogenetic stimulation of melanin-concentrating hormone (MCH)-expressing neurons in the lateral hypothalamus selectively extends the duration of paradoxical sleep episodes in mice. Activation of MCH fibers in the tuberomammillary nucleus leads to the release of GABA and a similar increase in paradoxical sleep stability.

    • Sonia Jego
    • Stephen D Glasgow
    • Antoine R Adamantidis
    Research
    Nature Neuroscience
    Volume: 16, P: 1637-1643
  • During NREM sleep, spindles emerge from thalamocortical interactions. Here the authors carry out multisite thalamic and cortical recordings in freely behaving mice, to investigate the role of other non-classical thalamic sites in sleep spindle generation.

    • Mojtaba Bandarabadi
    • Carolina Gutierrez Herrera
    • Antoine R. Adamantidis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Newly emerging techniques will revolutionize our understanding of the mammalian brain. Deisseroth and colleagues detail the development and use of microbial opsins as optogenetic tools for the study of neural circuits and discuss the use of these tools as potential future therapies for neurological disorders.

    • Feng Zhang
    • Alexander M. Aravanis
    • Karl Deisseroth
    Reviews
    Nature Reviews Neuroscience
    Volume: 8, P: 577-581
  • This study shows that tonic firing of centromedial thalamic neurons triggers rapid arousal, whereas burst firing triggers brain-wide propagating cortical slow waves and promotes sleep recovery, indicative of a midline thalamus sleep–wake hub.

    • Thomas C. Gent
    • Mojtaba Bandarabadi
    • Antoine R. Adamantidis
    Research
    Nature Neuroscience
    Volume: 21, P: 974-984
  • Ependymal cell cilia regulate cerebrospinal fluid flow through the cerebral ventricles. Here the authors show that the metabolic peptide melanin-concentrating hormone (MCH) increases cilia beat frequency in the third ventricle, and a lack of the MCH receptor increases ventricle size.

    • GrĂ©gory Conductier
    • FrĂ©dĂ©ric Brau
    • Alice Guyon
    Research
    Nature Neuroscience
    Volume: 16, P: 845-847
  • The complex spatiotemporal organization and regulation of sleep-related brain activity has been appreciated only in the past decade. Here, Adamantidis and colleagues review neurobiological mechanisms underlying local and large-scale neuronal network oscillations in the sleeping mammalian brain and how they relate to the global architecture of sleep.

    • Antoine R. Adamantidis
    • Carolina Gutierrez Herrera
    • Thomas C. Gent
    Reviews
    Nature Reviews Neuroscience
    Volume: 20, P: 746-762
  • The authors identify a new arousal circuit in the mammalian brain. They provide correlative and optogenetic evidence indicating that a subset of hypothalamic cells drive awakening from non-rapid eye movement (slow-wave) sleep and emergence from anesthesia by exerting a strong inhibitory tone onto reticular thalamic neurons.

    • Carolina Gutierrez Herrera
    • Marta Carus Cadavieco
    • Antoine Adamantidis
    Research
    Nature Neuroscience
    Volume: 19, P: 290-298
  • OxLight1 is a genetically encoded sensor for the orexin neuropeptides. It has been applied in fiber photometry recordings and two-photon imaging in mice during a variety of behaviors.

    • LoĂŻc Duffet
    • Seher Kosar
    • Tommaso Patriarchi
    Research
    Nature Methods
    Volume: 19, P: 231-241
  • Increased neuronal activity and reduced sleep quality emerge in the early stages of Alzheimer’s disease (AD). Calafate et al. show that the sleep–active hypothalamic MCH system is involved in neuronal homeostasis but fails in the early stages of AD.

    • Sara Calafate
    • Gökhan Ă–zturan
    • Joris de Wit
    ResearchOpen Access
    Nature Neuroscience
    Volume: 26, P: 1021-1031
  • Hypothalamic neurons expressing melanin-concentrating-hormone (MCH) maintain body weight by orchestrating behaviour and metabolism, but little is known about their intrinsic regulation. Here, Gonzalez and colleagues reveal their behaviour-related dynamics during wakefulness, and map their brain-wide neural inputs.

    • J. Antonio González
    • Panagiota Iordanidou
    • Denis Burdakov
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9
  • Changes in EEG delta-activity are widely used as proxy of sleep propensity. Here the authors demonstrate in mice and humans the presence of two types of delta-waves, only one of which reports on prior sleep-wake history with dynamics denoting a wake-inertia process accompanying deepest non-rapid-eye-movement sleep (NREM) sleep.

    • Jeffrey Hubbard
    • Thomas C. Gent
    • Paul Franken
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • In the past 20 years, understanding of the clinical manifestations, aetiopathophysiology, diagnosis and treatment of narcolepsy has greatly advanced. In this Review, Bassetti et al. present these advances, discuss unmet needs and offer future perspectives for the field of narcolepsy.

    • Claudio L. A. Bassetti
    • Antoine Adamantidis
    • Yves Dauvilliers
    Reviews
    Nature Reviews Neurology
    Volume: 15, P: 519-539