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Showing 1–11 of 11 results
Advanced filters: Author: Antoinette S. Perry Clear advanced filters

  • Wastewater-based surveillance tends to focus on specific pathogens. Here, the authors mapped the wastewater virome from 62 cities worldwide to identify over 2,500 viruses, revealing city-specific virome fingerprints and showing that wastewater metagenomics enables early detection of emerging viruses.

    • Nathalie Worp
    • David F. Nieuwenhuijse
    • Miranda de Graaf
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Semantic heterogeneity exists regarding terminology for active surveillance (AS) for prostate cancer. A panel of leading specialists in prostate cancer and AS involved in the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium participated in a consensus-forming project to reach international consensus on definitions of terms related to this management option. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.

    • Sophie M. Bruinsma
    • Monique J. Roobol
    • Sophie Bruinsma
    ReviewsOpen Access
    Nature Reviews Urology
    Volume: 14, P: 312-322

  • Understanding the emergence, evolution, and transmission of antibiotic resistance genes (ARGs) is essential to combat antimicrobial resistance. Here, Munk et al. analyse ARGs in hundreds of sewage samples from 101 countries and describe regional patterns, diverse genetic environments of common ARGs, and ARG-specific transmission patterns.

    • Patrick Munk
    • Christian Brinch
    • Frank M. Aarestrup
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Low read depth sequencing of whole genomes and high read depth exomes of nearly 10,000 extensively phenotyped individuals are combined to help characterize novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with lipid-related traits; in addition to describing population structure and providing functional annotation of rare and low-frequency variants the authors use the data to estimate the benefits of sequencing for association studies.

    • Klaudia Walter
    • Josine L. Min
    • Weihua Zhang
    ResearchOpen Access
    Nature
    Volume: 526, P: 82-90

  • Imputation uses genotype information from SNP arrays to infer the genotypes of missing markers. Here, the authors show that an imputation reference panel derived from whole-genome sequencing of 3,781 samples from the UK10K project improves the imputation accuracy and coverage of low frequency variants compared to existing methods.

    • Jie Huang
    • Bryan Howie
    • Nicole Soranzo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • MicroRNAs (miRNAs) have been implicated in prostate cancer initiation and progression, as well as response to cancer treatment. Here, O'Kelly and colleagues describe the basics of miRNA biology before discussing the available data on the role of miRNAs in the response of prostate tumours to hormone therapy, chemotherapy and radiation therapy.

    • Fardod O'Kelly
    • Laure Marignol
    • Donal Hollywood
    Reviews
    Nature Reviews Urology
    Volume: 9, P: 397-407

  • Epigenetic changes, such as gain and loss of DNA methylation and altered histone modifications, are a hallmark of human cancer. The role of the epigenome in prostate cancer is well recognized. In this Review, the authors discuss the different epigenetic modifications which can contribute to cancer progression, and consider the therapeutic potential of targeting the epigenome in patients with prostate cancer.

    • Antoinette S. Perry
    • R. William G. Watson
    • Donal Hollywood
    Reviews
    Nature Reviews Urology
    Volume: 7, P: 668-680