Prdm14 is expressed in embryonic stem (ES) cells and germ cells. It is now shown that this transcription factor safeguards the stem cell state by preventing development of mouse ES cells into extraembryonic endoderm cells by repressing loci related to differentiation along this developmental pathway. This suggests that Pdrm14 is part of the network of factors that maintains the ES cell state in mice.
- Ziyang Ma
- Tomek Swigut
- Joanna Wysocka
