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Showing 1–3 of 3 results
Advanced filters: Author: Antonija Kreso Clear advanced filters

  • The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition

    • Evelyne Lima-Fernandes
    • Alex Murison
    • Catherine A. O’Brien
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Cancer stem cells are thought to be resistant to anticancer therapies and are able to repopulate tumors and sustain tumor growth. The authors establish BMI-1 as a crucial regulator of cancer cell stemness in colorectal tumors and develop a chemical inhibitor that targets cancer stem cell renewal by reducing the levels of BMI-1. This strategy affords antitumor effects in vitro and in vivo and may pave the way for the precise targeting of elusive cancer stem cells.

    • Antonija Kreso
    • Peter van Galen
    • Catherine A O'Brien
    Research
    Nature Medicine
    Volume: 20, P: 29-36

  • Molecular, pharmacological and functional data show that haematopoietic stem cells (HSCs) are predisposed to ER-stress-mediated apoptosis compared to closely related progenitors; a framework for understanding how stress signalling is coordinated within the hematopoietic hierarchy and integrated with stemness is provided, and may have implications for the improvement of clinical transplantation of HSCs.

    • Peter van Galen
    • Antonija Kreso
    • John E. Dick
    Research
    Nature
    Volume: 510, P: 268-272