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Showing 1–4 of 4 results
Advanced filters: Author: Antonin Marchais Clear advanced filters

  • Olivier Voinnet and colleagues characterize the sequence of molecular events underyling the activation, proliferation and eventual silencing of an endogenous retrotransposon in Arabidopsis thaliana. They further show how this transient mobilization causes widespread genome diversification and de novo epiallelism that could serve as sources of selectable and potentially adaptative traits.

    • Arturo Marí-Ordóñez
    • Antonin Marchais
    • Olivier Voinnet
    Research
    Nature Genetics
    Volume: 45, P: 1029-1039

  • MicroRNAs are known to regulate myelination in the peripheral nervous system, but the underlying mechanisms remain unclear. Here the authors show that the Lin28B/let-7 axis drives the onset of myelination by promoting Krox20 expression through suppression of Notch signalling.

    • Deniz Gökbuget
    • Jorge A. Pereira
    • Ueli Suter
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Protein phosphatase1 (PP1), a signalling and transcriptional regulator, and epigenetic modulator is known to be a memory suppressor. Here the authors show that memory control by PP1 involves the microRNA cluster miR-183/96/182, and that this cluster is selectively regulated during memory formation in mice.

    • Bisrat T. Woldemichael
    • Ali Jawaid
    • Isabelle M. Mansuy
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • A collection of 131 multi-panel pediatric tumor PDX models are generated and characterized in a comprehensive effort to provide support for basic and translational research and treatment development in advanced pediatric malignancies.

    • Maria Eugénia Marques Da Costa
    • Sakina Zaidi
    • Birgit Geoerger
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-15