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Showing 1–3 of 3 results
Advanced filters: Author: Antonin Tutter Clear advanced filters

  • High-content protein arrays were used to identify cysteine dioxygenase (CDO1) as a small-molecule glue target for the von Hippel–Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal degradation of CDO1 in cells.

    • Antonin Tutter
    • Dennis Buckley
    • Gregory A. Michaud
    Research
    Nature Chemical Biology
    P: 1-9

  • A cell-based phenotypic screen led to the discovery of compounds called NVS-STGs, which bind to the N-terminal domain of STING and act as a molecular glue to induce higher-order oligomerization and activation.

    • Jie Li
    • Stephen M. Canham
    • Yan Feng
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 365-372