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Showing 1–4 of 4 results
Advanced filters: Author: Antonis M. Messinis Clear advanced filters

  • The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.

    • Maximilian Stangier
    • Antonis M. Messinis
    • Lutz Ackermann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • A highly efficient stereoselective C−H alkylation of indoles with aryl alkenes is achieved by sustainable iron catalysis, leading to atropoenriched and enantioenriched substituted indoles with high structural diversity. Detailed mechanistic studies by experiment, Mössbauer spectroscopy and computation reveal the origin of the catalytic efficacy and stereoselectivity.

    • Zi-Jing Zhang
    • Nicolas Jacob
    • Lutz Ackermann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • C–H activation in organic chemistry usually relies on precious and toxic transition metals. Now it is reported that a sustainable photo-promoted iron-catalysed aromatic imine C–H alkenylation reaction with alkynes circumvents previous limitations of related iron-catalysed reactions that required additives or high reaction temperatures.

    • Antonis M. Messinis
    • Tristan von Münchow
    • Lutz Ackermann
    Research
    Nature Catalysis
    Volume: 7, P: 273-284

  • Despite the many recent developments in iron-catalysed cross-couplings, the mechanistic understanding of these reactions is lacking compared to the more studied palladium and nickel variants. Here, the authors find that during iron-catalysed Negishi reactions the diphosphine ligand predominately binds to the zinc—rather than the iron—centre.

    • Antonis M. Messinis
    • Stephen L. J. Luckham
    • Robin B. Bedford
    Research
    Nature Catalysis
    Volume: 2, P: 123-133