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Showing 1–4 of 4 results
Advanced filters: Author: Anupriya Singhal Clear advanced filters

  • Tools to label single neurons and track their development inC. elegans have been lacking. Singhal et al. optimized a method, which applies infrared laser to induce heat-dependent gene expression at cellular resolution in developing C. elegansembryos, and show that it can uncover new aspects of embryo morphogenesis.

    • Anupriya Singhal
    • Shai Shaham
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour.

    • Menachem Katz
    • Francis Corson
    • Shai Shaham
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Recent developments in bioengineering and organic chemistry have enabled targeting of the previously ‘undruggable’ KRAS; this review summarizes the successes, challenges and future of KRAS therapeutics in the clinic.

    • Anupriya Singhal
    • Bob T. Li
    • Eileen M. O’Reilly
    Reviews
    Nature Medicine
    Volume: 30, P: 969-983