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Showing 1–7 of 7 results
Advanced filters: Author: Anushree Chatterjee Clear advanced filters

  • Using agar media suspended in pipette tips and a standard camera, the geometric viability assay provides a user-friendly and scalable update to standard colony-forming-unit-count approaches.

    • Christian T. Meyer
    • Grace K. Lynch
    • Joel M. Kralj
    ResearchOpen Access
    Nature Microbiology
    Volume: 8, P: 2304-2314

  • Otoupal et al. use a systematic approach to investigate the effects of fitness neutral gene perturbations and antibiotic synergy in Escherichia coli. These neutral fitness interactions worked as co-therapies in a Salmonella enterica infection and informed the design of re-sensitization therapies in multi-drug resistant E. coli and Klebisiella pneumoniae clinical isolates.

    • Peter B. Otoupal
    • Kristen A. Eller
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15

  • Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery approach by repurposing the bacterial Type III secretion system in conjunction with a kill switch to overcome limited transport of PNAs into mammalian cells.

    • Kristen A. Eller
    • Thomas R. Aunins
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13

  • Peter Otoupal et al. present CHAOS, an approach for preventing the development of antibiotic resistance in E. coli through CRISPR-Cas9-based perturbation of gene expression. They show that multiplexed perturbations decrease fitness of clinically-isolated Carbapenem-resistant E. coli upon antibiotic exposure.

    • Peter B. Otoupal
    • William T. Cordell
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-13

  • The rich ethnolinguistic and sociocultural differences that exist in India offers a unique opportunity to study human diversity. With the whole genomes of 10,000 healthy and unrelated Indians from 83 populations, the GenomeIndia project captures the genetic diversity of one of the highly underrepresented populations in the global genomics landscape.

    • Chandrika Bhattacharyya
    • Krithika Subramanian
    • Bratati Kahali
    Comments & Opinion
    Nature Genetics
    Volume: 57, P: 767-773