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Showing 1–2 of 2 results
Advanced filters: Author: Aochiu Chen Clear advanced filters

  • The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights into the catalytic mechanism underlying C-C bond forming reactions.

    • Jeffrey T. Mindrebo
    • Ashay Patel
    • Michael D. Burkart
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Structures of the ketosynthase–chain length factor complex from ishigamide biosynthesis, cross-linked to the acyl carrier protein, reveal the molecular interactions between these domains and how the reaction pocket limits rounds of product extension.

    • Danyao Du
    • Yohei Katsuyama
    • Yasuo Ohnishi
    Research
    Nature Chemical Biology
    Volume: 16, P: 776-782