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Molecular Basis for Catalysis and Regulation of the Strigolactone Catabolic Enzyme CXE15

Using crystallography and in planta analysis, Shahul Hameed et al. reveal how ROS-induced disulphide bonding inhibits the strigolactone-degrading enzyme CXE15, uncovering a redox-sensitive mechanism for regulating hormone catabolism in plants.

Umar F. Shahul Hameed
Aparna Balakrishna
Stefan T. Arold
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14

Zaxinone is a novel ligand of the strigolactone (SL) receptor DWARF14 (D14) in Arabidopsis. It competitively binds the active site of D14 and acts as a long-lasting, non-hydrolysable antagonist of SL by blocking the interaction between D14 and MAX2.

Juan C. Moreno
Umar F. Shahul Hameed
Salim Al-Babili
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Chromosome-scale pearl millet genomes reveal CLAMT1b as key determinant of strigolactone pattern and Striga susceptibility

Production of pearl millet is impacted by the root parasitic weed Striga hermonthica. Here, the authors assemble the genomes of resistant and susceptible lines of pearl millet and identify a critical gene CARLACTONOIC ACID METHYLTRANSFERASE1b (CLAMT1b) in determining Striga resistance.

Hendrik N. J. Kuijer
Jian You Wang
Salim Al-Babili
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-12
The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

Strigolactone and abscisic acid are carotenoid-derived plant hormones. Here the authors describe the identification of zaxinone, a further apocarotenoid metabolite, which down-regulates strigolactone content and is required for normal growth and development in rice.

Jian You Wang
Imran Haider
Salim Al-Babili
ResearchOpen Access18 Feb 2019
Nature Communications

Volume: 10, P: 1-9

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Molecular Basis for Catalysis and Regulation of the Strigolactone Catabolic Enzyme CXE15

Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14

Chromosome-scale pearl millet genomes reveal CLAMT1b as key determinant of strigolactone pattern and Striga susceptibility

The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

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